Metal complexes of Glipizide drug were prepared and characterized based on elemental analysis, FT-IR, Molar conductance and thermal analysis (TGA technique). From elemental analysis data, the complexes were proposed to have general formulae (C₂₁H₂₅N₅O₄S)2M. The molar conductance data reveals that both the complexes are non-electrolyte, IR spectra shows that the drug is coordinated to the metal ions in a neutral bidentate manner with OO donor sites of the amide O and sulphone O, from the ESR spectra, it is found that that the geometrical structures of these complexes are tetrahedral. The thermal behaviour of these complexes were studied using thermo gravimetric analysis technique. The result obtained shows that the hydrated complexes lose water molecules of hydration followed immediately by decomposition of the anions and the ligand molecules in the successive stages. Thermogravimetric analysis was carried out to study the decomposition and various kinetic parameters. Freeman Carroll and Sharp Wentworth method have been applied for calculation of kinetic parameters, while the data from Freeman Carroll method have been used to determine various thermodynamic parameters such as order of reaction, entropy change, free energy change and apparent entropy change.