A big challenge, academic world and industry is facing the relationship of modern societies to the environment that requires reinventing the manufacture and use of materials. Synthetic methodologies now a day should be designed to use and generate substances that possess little or no toxicity to human health and the environment The miceowave assisted synthesis and characterization of Zn (II) complexes of Schiff bases derived from three diuretic drugs acetazolamide, furosemide and hydrochlorothiazide are reported here. The ligand and complexes have been suitably synthesized and isolated in crystalline form. Molar conductance values suggest the non-electrolytic nature of the complexes.On the basis of elemental analyses, electrical conductivity data and molecular weight data the adducts are assigned to the general composition [M(L)₂].All the adducts are diamagnetic in nature. The IR studies indicate that ligand is coordinated to metal through azomethine nitrogen atom. The diuretic activity of the ligand FSM-SA and complex FSM-SA-Zn was assessed in vivo following the protocol of Institutional Animal Ethical Committee norms. While studying the results of the experiment it was concluded the diuretic activity of the FSM-SA and FSM-SA-Zn was found to be more than the parent drug. Partical size studies further suggest that the size of metal complexes is smaller than the drug molecule.