eng Oriental Scientific Publishing Company Material Science Research India 0973-3469 2019-12-20 16 3 189 197 15303 article An Overview of Synthetic Approaches towards of Nitration of α-Tetralones Aeysha Sultan 1 Abdul Rauf Raza 2 Mian Habib Ur Rehman Mehmood 1 Bushra Nisar 3 Syeda Laila Rubab 1 Ali Irfan 3 Department of Chemistry, Faculty of Science and Technology, University of Education, Lahore, Pakistan Ibn e Sina Block, Department of Chemistry, University of Sargodha, Sargodha-40100, Pakistan Department of Chemistry, University of Lahore, Sargodha Campus, Sargodha-40100, Pakistan Facultad de Ingeniería y Tecnología. Universidad San Sebastián, Bellavista 7, Santiago 8420524, Chile.

The 1-tetralone scaffold and its derivatives are not only important as pharmacological agents but these also serve as precursors for natural products and compounds of medicinal importance. The easiest way to introduce a substituent on an aromatic as well as aliphatic system is nitration. Once introduced, the –NO2 group can be easily replaced by a wide range of functional groups. The review aims to highlight strategies for nitration of substituted and unsubstituted 1-tetralone which led to introduction of NO2 functionality at various positions. 

Vol_16_No_3_ano_aey_eq_1

 https://www.materialsciencejournal.org/vol16no3/an-overview-of-synthetic-approaches-towards-of-nitration-of-%ce%b1-tetralones/ Aliphatic Substitution Intramolecular Cyclization Nitration 1-Tetralone