eng Oriental Scientific Publishing Company Material Science Research India 0973-3469 2022-05-10 19 1 17 25 19543 article Alaa Fehaid 1 Sara T. Elazab 2 Mona G. Elhadidy 3 Eman Mohamad El Nashar 4 Asim Mohammed Abdalla 5 Khulood Mohammed Al-Khater 6 Forensic Medicine and Toxicology department, Faculty of Veterinary Medicine, Mansoura University, Egypt Pharmacology department, Faculty of Veterinary Medicine, Mansoura University, Egypt Medical physiology, faculty of Medicine, Mansoura University, Egypt, and Physiology department, faculty of Medicine, Albaha University, KSA Department of Anatomy, college of Medicine, King Khalid University, Abha 61421, Saudi Arabia. King Khalid University Anatomy department, Faculty of Medicine, King Khalid University, KSA. Abha 61421, Saudi Arabia Department of Anatomy, College of Medicine, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi Arabia Silver nanoparticles have been shown to increase postnatal toxicity in breastfeeding female rats, with negative consequences for their offspring. We wanted to investigate more about the differences in toxicity between silver nitrate and silver nanoparticles, as well as the impact of zinc chloride treatment on the silver nitrate induced toxicity on female albino rats. For 21 days, 30 breastfeeding female albino rats were divided into 4 groups; the first three group received orally 0, 50,100 mg/kg of silver nitrate. While the fourth group received 100 mg/kg of silver nitrate plus 300 ppm of zinc chloride in drinking water and fifth group received only AG-NPs at dose of 100 ppm.  The results demonstrated that silver nitrate were more hazardous than nano-silver, as evidenced by higher free radical release, increased MDA levels, and decreased antioxidant enzyme levels (SOD). In addition, the silver ions-treated group had higher levels of liver enzymes and creatinine. https://www.materialsciencejournal.org/vol19no1/zinc-chloride-ameliorates-the-adverse-effects-of-silver-nitrates-compared-to-silver-nanoparticle-in-post-natal-model-of-toxicity/ Hepatorenal Functions MDA Silver Nitrates Silver Ions sod1