A sensitive differential pulse voltammetric (DPV) method for the determination of Ranitidine (RAN) at bare carbon paste electrode (CPE) and zeolite modified carbon paste electrode (ZMCPE) was developed. Compared to bare carbon paste electrode (CPE), ZMCPE exhibited increased sensitivity. Quantitative determination was achieved in the concentration range of 6.2 x 10-8 M to 4.4 x 10-7 M and 1.2 x 10-9 to 2.2 x 10-8 M for CPE and ZMCPE respectively. LOD and LOQ were found to be 1.9 x 10-8 and 0.633 x 10-7 M; 3.1 x 10-9 M and 1.03 x 10-8 M for CPE and ZMCPE respectively. Factors affecting peak currents such as accumulation time, accumulation potential, pH of buffer solution were examined. The proposed method has been successfully applied for the determination of RAN in pharmaceutical formulations and biological samples.