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  <record>
    <language>eng</language>
    
      <publisher>Oriental Scientific Publishing Company</publisher>
    
    <journalTitle>Material Science Research India</journalTitle>
    
      <issn>0973-3469</issn>
    
    
    <publicationDate>2008-11-10</publicationDate>
    

        <volume>5</volume>

        <issue>2</issue>

 

    <startPage>481</startPage>
    <endPage>484</endPage>

   
      <doi></doi>
    
    <publisherRecordId>2105</publisherRecordId>
    <documentType>article</documentType>
    <title language="eng">Visible Spectrophotometric Methods for the Quantitative Estimation of Eplerenone in their Formulations</title>

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    </authors>
    
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    <abstract language="eng"><p>Two simple, sensitive and economical visible spectrophotometric methods were developed for the analysis of Eplerenone in pure form as well as in pharmaceutical formulations. The Method-A is based on the formation of meisenheimer like sigma -complex by the m-dinitrobenzene with the mentioned drug in presence of alkaline medium to from a colored chromogen measured at 490 nm. The Method-B is based on condensation between INH (Iso nicotinic acid hydrazide) and mentioned drug in presence of acidic medium to from a colored chromogen measured at 440 nm. The results of analysis have been validated statistically and recovery studies confirmed the accuracy of proposed methods. The methods were successfully applied to the determination of eplerenone in pharmaceutical formulations.</p></abstract>

    <fullTextUrl format="html">https://www.materialsciencejournal.org/vol5no2/visible-spectrophotometric-methods-for-the-quantitative-estimation-of-eplerenone-in-their-formulations/</fullTextUrl>




      <keywords language="eng">
        <keyword>Eplerenone</keyword>
      </keywords>


      <keywords language="eng">
        <keyword> Isonicotinic acid hydrazide (INH)</keyword>
      </keywords>


      <keywords language="eng">
        <keyword> Meisenheimer sigma -complex</keyword>
      </keywords>

  </record>

</records>