The need for rapid evaluation of chemicals in the environment or human body has prompted researchers to develop easy to use biological assays or biosensors. The new developments in light sensitive and conductive polymers integrated with micro-optics can monitor “practically anything“ such as toxicity to DNA, life (cytotoxicity), endocrine disrupting chemicals or environmental pollutants. Such new generation biochips offer a panoramic view of once unthinkable diagnostics, propelling the laboratory into nanoscale dimensions.