Visible Spectrophotometric Methods for the Quantitative Estimation of Eplerenone in their Formulations

Abstract
Keywords
Introduction
Materials and Methods
Results
Discussion
Conclusion
Acknowledgement
Funding Sources
Conflict of Interest
Data Availability Statement
Ethics Statement
References

Article | Open Access

Visible Spectrophotometric Methods for the Quantitative Estimation of Eplerenone in their Formulations

Volume 5, Number 2

D. Ravi Kumar¹, V. Naga Lakshmi¹, S.V.M. Vardhan² and C. Rambabu³*

¹Department of Chemistry,

²Department of Biochemistry,

³Department of Chemistry, Acharya Nagarjuna University Nuzvid Campus, Nuzvid (India).

DOI : http://dx.doi.org/10.13005/msri/050234

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ABSTRACT:

Two simple, sensitive and economical visible spectrophotometric methods were developed for the analysis of Eplerenone in pure form as well as in pharmaceutical formulations. The Method-A is based on the formation of meisenheimer like sigma -complex by the m-dinitrobenzene with the mentioned drug in presence of alkaline medium to from a colored chromogen measured at 490 nm. The Method-B is based on condensation between INH (Iso nicotinic acid hydrazide) and mentioned drug in presence of acidic medium to from a colored chromogen measured at 440 nm. The results of analysis have been validated statistically and recovery studies confirmed the accuracy of proposed methods. The methods were successfully applied to the determination of eplerenone in pharmaceutical formulations.

KEYWORDS:

Eplerenone; Isonicotinic acid hydrazide (INH); Meisenheimer sigma -complex

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