Development of Sustained Release Drug Delivery System of Lithium Carbonate and in Vitro Evaluation

Abstract
Keywords
Introduction
Materials and Methods
Results
Discussion
Conclusion
Acknowledgement
Funding Sources
Conflict of Interest
Data Availability Statement
Ethics Statement
References

Article | Open Access

Development of Sustained Release Drug Delivery System of Lithium Carbonate and in Vitro Evaluation

T.K. Pal¹, J. Khanam² and S. SiddiquE¹

¹Department of Pharmaceutics, Radharaman College of Pharmacy, Bhopal - 462 003 (India)

²Division of Pharmaceutical Engineering, Department of Pharmaceutical Technology, Jadavpur University, Kolkata - 700 032 (India)

DOI : http://dx.doi.org/10.13005/msri/032a27

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ABSTRACT:

The purpose of this study was to investigate the effect of different proportions of HPMC polymer in the release of drug from the hydrophilic matrix tablets. Three formulations were made by wet granulation method 450mg Lithium carbonate and 10%, 20% & 30% HPMC were granulated with Ethanolic solution of Eudragit S100, dried and then compressed to formulate the tablets. In vitro studies were conducted on the three formations. All the three formulations demonstrated relatively sustained release behavior but the matrix tables containing 30% HPMC exhibited suitable release kinetics.

KEYWORDS:

Drug delivery system; lithium carbonate; invitro evaluation

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