Synthesis, Determination of Partition Coefficient and Antimicrobial Activity of Triazolo Thiadiazinyl Bromocoumarin Derivatives

Abstract
Keywords
Introduction
Materials and Methods
Results
Discussion
Conclusion
Acknowledgement
Funding Sources
Conflict of Interest
Data Availability Statement
Ethics Statement
References

Article | Open Access

Synthesis, Determination of Partition Coefficient and Antimicrobial Activity of Triazolo Thiadiazinyl Bromocoumarin Derivatives

Volume 3, Number 2a

B.S. Jayshree^a*, A.R. Sahu², M. Srinivasa Murthy² and K.N. Venugopala²

¹Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal - 576 104 (India)

²Department of Pharmaceutical Chemistry, Al-Ameen College of pharmacy, Hosur Road, Bangalore - 560 027 (India)

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ABSTRACT:

A series of triazolo-thiadiazinyl bromocoumarins (10a-k) were synthesized and the compounds were characterized by IR, 1H-NMR and Mass spectral analysis. The partition coefficient, a hydrophobic parameter was also determined for the newly synthesized compounds and the same were subjected for their antimicrobial activity.

KEYWORDS:

Bromocoumarin; Triazole; Thiadiazine; Antimicrobial activity; Partition coefficient

Article Publishing History

Received on: 25 Oct 2005
Accepted on: 30 Nov 2006