Electroanalysis of Ranitidine (RAN) in Pharmaceutical Formulations and Biological Samples at Modified Electrodes

Abstract
Keywords
Introduction
Materials and Methods
Results
Discussion
Conclusion
Acknowledgement
Funding Sources
Conflict of Interest
Data Availability Statement
Ethics Statement
References

Article | Open Access

Electroanalysis of Ranitidine (RAN) in Pharmaceutical Formulations and Biological Samples at Modified Electrodes

Volume 5, Number 2

C. Narasimha Rao¹, K. Balaji¹, C. Narasimha Rao² and P. Venkateswarlu¹*

¹Department of Chemistry, Sri Venkateswara University, Tirupati-517 502 (India).

²Department of Zoology, Sri Venkateswara University, Tirupati-517 502 (India).

DOI : http://dx.doi.org/10.13005/msri/050208

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ABSTRACT:

A sensitive differential pulse voltammetric (DPV) method for the determination of Ranitidine (RAN) at bare carbon paste electrode (CPE) and zeolite modified carbon paste electrode (ZMCPE) was developed. Compared to bare carbon paste electrode (CPE), ZMCPE exhibited increased sensitivity. Quantitative determination was achieved in the concentration range of 6.2 x 10-8 M to 4.4 x 10-7 M and 1.2 x 10-9 to 2.2 x 10-8 M for CPE and ZMCPE respectively. LOD and LOQ were found to be 1.9 x 10-8 and 0.633 x 10-7 M; 3.1 x 10-9 M and 1.03 x 10-8 M for CPE and ZMCPE respectively. Factors affecting peak currents such as accumulation time, accumulation potential, pH of buffer solution were examined. The proposed method has been successfully applied for the determination of RAN in pharmaceutical formulations and biological samples.

KEYWORDS:

Ranitidine; differintial pulse voltammetry; cyclic voltammetry; zeolite

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