A Validated RP-HPLC Method for Estimation of Glipizide in it?S Pure and Pharmaceutical Dosage Form (Tablets)
*Department of Chemistry, Bapuji Institute of Engineering and Technology, Davangere, Karnataka - 577 004 (India).
DOI : http://dx.doi.org/10.13005/msri/060131
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A simple, specific and precise high performance liquid chromatographic method has been developed for estimation of Glipizide in its pure and pharmaceutical dosage forms. A HPLC system consisting of a gradient pump, reverse phase C-18 analytical column, a variable UV-Visible detector set at 225 nm and an integrator was used. The mobile phase consisted of methanol and 0.115%w/v ammonium dihydrogen phosphate buffer and pumped at 1ml/min at ambient temperature. This RP-HPLC method was validated for its linearity, precision and accuracy. The calibration curve was linear in the range of 10 to 70 μg/ml).
KEYWORDS:Glipizide; HPLC; Hypurity C18 analytical column; placebo; tablets
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693 Accepted on: 28 Jan 2009
